挪威B群脑膜炎球菌外膜囊（OMV）菌苗是用脱氧胆酸盐从脑膜炎球菌株44/76-SL（B:15:P1.7,16:L3,7,9）中抽提的OMV,经AL（OH）_3吸附制成的。每剂（0.5ml）含25μg蛋白、2μg脂多糖（LPS）和1.67mg Al（OH）_3。选择无脑膜炎球菌病史及低抗B群脑膜炎球菌IgG抗体水平（<1μg/ml）的10名健康成人志愿者为接种对象,在0、6、46周经三角肌接种OMV菌苗。分别于接种前、第1、2剂接种后2和6周、第3剂接种 Norwegian group B meningococcal outer membrane vesicles (OMV) vaccine was extracted with deoxycholate from meningococcal strain 44/76-SL (B: 15: P1.7,16: L3,7,9) Of OMV, made by the adsorption of AL (OH) 3. 25 μg of protein, 2 μg lipopolysaccharide (LPS) and 1.67 mg Al (OH) _3 per dose (0.5 ml). Ten healthy volunteers with no history of meningococcal disease and low anti-BS meningococcal IgG antibody levels (<1 μg / ml) were vaccinated and OMV vaccine was inoculated into the deltoid muscle at 0, 6 and 46 weeks. Before inoculation, the first and second inoculation 2 and 6 weeks after the third dose