麻黄碱与其异构体——伪麻黄碱具有不同的药理活性,并且麻黄碱作为合成冰毒(苯丙胺)的主要原料,是法庭严格查禁的毒品之一.在实际工作中,经常需要将两者区分开.作者首次利用电喷雾质谱的源内碰撞诱导解离技术,实现了将两者区分开的目的,并利用该方法对一可疑样品进行了检测,证实为麻黄碱. Ephedrine and its isomer, pseudoephedrine, have different pharmacological activities, and as the main raw material for the synthesis of methamphetamine (methamphetamine), ephedrine is one of the most strictly banned drugs in the courts, and in practice, it is often necessary to distinguish the two. The first time, the electrospray ionization source-end collision-induced dissociation technique was used to separate the two. This method was used to detect a suspicious sample and confirmed as ephedrine.