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10~(-8)mol/L、5.5×10~(-8)mol/L、10~(-7)mol/L的硫酸吗啡使体外培养的乳鼠心肌细胞搏动频率分别增加9%、32%和81%。具有量效关系。纳络酮(10~(-5)mol/L)能完全取消吗啡的此种作用。而普萘洛尔(10~(-5)mol/L)却不影响吗啡的作用。这一结果提示吗啡可直接加快心肌细胞的搏动频率,可能是通过激动吗啡受体而作用的
The pulsatility of neonatal rat cardiomyocytes in 10 -8 mol / L, 5.5 × 10 -8 mol / L and 10 -7 mol / L morphine increased the cardiomyocyte pulsatility by 9%, 32% % And 81%. Has a dose-effect relationship. Naloxone (10 -5 mol / L) completely abolished this effect of morphine. Propranolol (10 ~ (-5) mol / L) did not affect the effect of morphine. This result suggests that morphine can directly accelerate the pulsatile frequency of cardiomyocytes, probably through the activation of morphine receptors