哌喹氮芥(Piperaquine mustine,PQM)系抗疟药哌喹结构上连接抗癌有效基因氮芥的抗癌药。本文报道PQM对多种动物移植性肿瘤的实验性治疗结果。 1 材料和方法 PQM本校抗疟药研究室提供,动物和瘤株均有上海药物研究所提供。实验方法参照文献,实体瘤系膜水型保种,选接种瘤源6～9d生成旺盛的腹水型作瘤源,在无菌操作下,注射在小鼠前肢腋窝皮下 Piperazine (Piperaquine mustine, PQM) is an anticancer drug which is structurally linked to piperazine, an anti-cancer effective gene, nitrogen mustard. This article reports the experimental treatment of PQM on a variety of animal transplanted tumors. 1 Materials and Methods PQM laboratory provided by the anti-malaria, animal and tumor strains are provided by the Shanghai Institute of Materia Medica. Experimental methods refer to the literature, solid tumor mesangial water-based seed selection tumor selection 6 ~ 9d source of strong ascites tumor origin, under sterile operation, injected in the mouse forelimb subcutaneous axillary