作者报道头孢替坦(Cefotetan)与头孢三嗪对照治疗无并发症淋球菌尿道炎和宫颈炎的疗效及安全性。172例患者按3∶3∶2分成三组,随机接受头孢替坦0.5g、1.0g或头孢三嗪钠0.25g,一次肌肉注射。治疗后定时测定血药浓度,并随访4～8天。起初接受头孢替坦0.5g治疗者63例,1.0g者65例和头孢三嗪治疗者44例。在可评估的123例中,男81例,女42例。全部男性和16例女性患者均有症状,淋病奈瑟氏球菌培养均阳性。结果表明,临床治愈时间最 The authors report the efficacy and safety of cefotetan versus ceftriaxone in the management of gonococcal urethritis and cervicitis without complications. One hundred and seventy-two patients were divided into three groups at 3: 3: 2 and were randomized to cefotetan 0.5 g, 1.0 g, or cefotaxime sodium 0.25 g once intramuscularly. After treatment, the blood concentration was measured at regular intervals and followed up for 4 to 8 days. 63 patients initially received cefotetan 0.5g, 65 patients received 1.0g and 44 patients received ceftriaxone. Among the 123 evaluable cases, 81 were male and 42 were female. All males and 16 females had symptoms and Neisseria gonorrhoeae cultures were positive. The results show that the most clinical cure time