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湿法制粒时,颗粒烘干程度掌握不准,常造成颗粒含水量太低,压片时出现裂片现象。即使不裂片,硬度也会很差,给实际生产带来很大困扰。我厂对烘干后含水量太低的颗粒喷加适量一定浓度酒精,进行处理,然后直接上机压片(湿颗粒压片),取得较好效果。以我厂复方丹参片为例,
When wet granulation, the degree of particle drying is inaccurate, often causing the particle water content to be too low, and cracking occurs when the tablet is pressed. Even if it is not split, the hardness will be very poor, which will cause great difficulties for the actual production. Our factory applies a certain amount of alcohol to the pellets with too low water content after drying, and then treats them directly, then directly compresses the tablets on the machine (wet pellets are pressed) to obtain better results. Take Dandan Tablet of our factory as an example.