甲苯磺丁脲(D_(860))是临床常用治疗非胰岛素依赖型糖尿病磺脲类口服降糖药物之一,降糖效果尚好,大多数患者未见明显不良反应.但我科在临床应用D_(860) 的治疗过程中,1例出现高热.[病例]女,45a,因发热1wk入院.患者于入院1wk前出现周身无力,就诊内科门诊,化验空腹血糖11.8 mmol/L,尿糖(?),诊断为糖尿病Ⅲ型.po D_(860)1.0g,tid治疗,此后患者间断出现发热、全身疼痛,iv gtt林可霉系治疗3d无效故入院.体征:T39.0℃,P108beats/min,BP12/8kPa(90～60 mmHg),热性病容,神清语利,无皮疹,周身浅表淋巴结不大,颈软,心肺无异常,腹软,无压痛,肝脾未触及.入院后有关辅助检查诸如胸片,B超(肝胆胰),ECG及血、尿、粪常规,血细菌培养,肥达反应,肝功等均未见明显异常.空腹血糖12.1mmol/L,尿糖(?),入院 Tolbutamide (D_ (860)) is one of the oral hypoglycemic drugs commonly used in the treatment of non-insulin-dependent diabetes sulfonylureas, hypoglycemic effect is good, most patients showed no obvious adverse reactions, but our department in the clinical application of D_ (860), 1 case of high fever. [Case] ​​Female, 45a, 1 week due to fever admitted to hospital. Patients presented with systemic weakness 1d before admission, medical clinic, fasting blood glucose 11.8 mmol / L, ), Diagnosis of diabetes type Ⅲ. Po D_ (860) 1.0g, tid treatment, after intermittent fever, systemic pain, iv gtt Lincomycin treatment was ineffective for 3 days and admitted to hospital Physical signs: T39.0 ℃, P108beats / min , BP12 / 8kPa (90 ~ 60 mmHg), Fever, Shen Qing language profits, no rash, whole body superficial lymph nodes, neck soft, no abnormal heart and lung, abdominal soft, no tenderness, liver and spleen not touched. There were no significant abnormalities in auxiliary examinations such as chest radiography, B ultrasound, blood glucose, urine, fecal routine, blood bacterial culture, Widal reaction, liver function, etc. Fasting plasma glucose 12.1 mmol / L, ?), Admitted to hospital