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目的：有机硒氰化合物的合成和肿瘤抑制作用研究。方法：通过苄基卤代、硒氰酸钾的取代反应制备了１５个苄基硒氰化合物，并对Ａ５４９ 人肺腺癌细胞和Ｐ３８８ 小鼠白血病肿瘤细胞生长进行了抑制试验。结果：１５ 个苄基硒氰化合物的结构都经过了分析确证；目标化合物对Ａ５４９ 人肺腺癌细胞和Ｐ３８８ 小鼠白血病肿瘤细胞的生长都有抑制作用。结论：其中一些化合物活性较好值得进一步研究。
Objective: To study the synthesis and tumor inhibition of organic selenium cyanide compounds. METHODS: Fifteen benzylselenocaproate compounds were prepared by the substitution of benzyl halides and potassium selenocyanates, and the growth inhibition of A549 human lung adenocarcinoma cells and P388 mice leukemia tumor cells was tested. Results: The structures of all the 15 benzylselenocapnic compounds were confirmed. The target compounds showed an inhibitory effect on the growth of A549 human lung adenocarcinoma cells and P388 mouse leukemia tumor cells. Conclusion: Some of these compounds should be further investigated for their activity.