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目的 本实验旨在研究生活在高海拔 4340米的人的红细胞压积及与血氧饱和度和性激素水平的关系。方法 测定 5 6例生活在利马 ( 1 5 0m)和 1 79例生活在秘鲁巴斯科州( 4 340m)妇女的相关数据 ,年龄从 2 0～ 70岁 ,指标包括身高、体重、血氧饱和度、硫酸脱氢表雄酮、睾丸酮、雌二醇和红细胞压积。计算体重指数 ,睾丸酮、雌激素比值。结果 高海拔的妇女红细胞压积随着年龄的增加而升高 ,而海平面生活的妇女没有变化。 2 0～ 39岁妇女红细胞压积从( 4 5 .62± 6.45 ) % (平均值±标准差 ) ,升高到 60～ 70岁时的 ( 5 3.2 8± 6.35 ) % (P <0 .0 0 0 1 )。红细胞值也随着年龄的增长而增加 ,从 2 0～ 39岁的 2 .46%升高到 60～ 70岁的 44.44%。高海拔妇女的红细胞压积的升高分别与低血氧饱和度 (P <0 .0 0 0 1 ) ;低雌二醇水平 (P <0 .0 0 0 3) ;睾丸酮 /雌二醇比值 (P <0 .0 1 )密切相关。多元回归分析显示低血氧饱和度 ,高睾丸酮雌二醇与红细胞压积升高有关 (P <0 .0 0 1 )。结论 生活在秘鲁安第斯山脉高海拔妇女的红细胞压积随着年龄的增加而升高。低血氧饱和度和血清高睾丸酮 /雌二醇比值可以解释这种增加
Objective The purpose of this study was to investigate the relationship between hematocrit and oxygen saturation and sex hormone levels in people at a height of 4340 meters. Methods Data were obtained for 56 women living in Lima (150m) and 1 79 women living in Basco (4 340m) in Peru, ranging in age from 20 to 70 years. The parameters included height, weight, blood oxygenation Saturation, DHEA, testosterone, estradiol and hematocrit. Calculate body mass index, testosterone, estrogen ratio. Results The hematocrit of women at high altitudes increased with age, while there was no change in women at sea level. The hematocrit of 20 ~ 39-year-old women increased from (45.62 ± 6.45)% (mean ± standard deviation) to (53.28 ± 6.35)% (P <0. 0) 0 0 1). Erythrocyte values also increased with age, from 2.46% at 20 ~ 39 years old to 44.44% at 60 ~ 70 years old. Elevated hematocrit in high-altitude women was correlated with hypoxemia (P <0.001), low estradiol level (P <0.00003), testosterone / estradiol ratio (P <0. 01) are closely related. Multivariate regression analysis showed that hypoxemia and high testosterone estradiol were associated with elevated hematocrit (P <0.01). Conclusion The hematocrit of women living in high altitude in Peruvian Andes rises with age. Low oxygen saturation and high serum testosterone / estradiol ratio may account for this increase