丙型肝炎病毒(HCV)是引起混和型冷球蛋白血症的病理因素之一。本文报道一例因HCV感染引起的膜增殖性肾小球肾炎及混和型冷球蛋白血症。患者,男,61岁,因四肢无力、关节痛及下肢紫癜入院。其血清转氨酶持续性增高,冷球型蛋白血症Ⅱ期5年以上,肝活检确诊非甲非乙型肝炎。患者肝肿大,血清天冬氨酸氨基转移酶60u/L(正常值<35),血清丙氨酸转移酶42IU/L(正常值<35),γ-谷氨酰转 Hepatitis C virus (HCV) is one of the pathogenic factors that cause mixed cryoglobulinemia. This article reports a case of membranoproliferative glomerulonephritis and mixed cryoglobulinemia due to HCV infection. Patient, male, 61 years old, was hospitalized due to weakness in his limbs, joint pain and purpuric lower limbs. The serum aminotransferase persistently increased, cold globulin stage Ⅱ more than 5 years, liver biopsy confirmed non-A non-B hepatitis. Patients with hepatomegaly, serum aspartate aminotransferase 60u / L (normal <35), serum alanine aminotransferase 42IU / L (normal <35), γ-glutamyl transfer