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目的 :研究肝炎后肝硬化合并消化性溃疡的临床特点 ,探讨小剂量普萘洛尔对肝硬化合并消化性溃疡愈合的影响。方法 :肝炎后肝硬化合并消化性溃疡 4 5例 ,随机分为治疗组 ( A组 ) 2 3例 ,口服普萘洛尔加西咪替丁 ;对照 1组 ( B组 ) 2 2例 ,口服维生素 B6加西咪替丁。另外选单纯性消化性溃疡 2 2例作为对照 2组 ( C组 ) ,治疗方法与 B组同。结果 :肝硬化合并消化性溃疡的发病中位年龄较单纯性消化性溃疡晚 12年 ,溃疡部位以胃溃疡居多 ,合并出血率高 ,与 C组比较有显著性差异 ( P<0 .0 1)。普萘洛尔可明显提高肝硬化合并消化性溃疡的愈合率 ,与 B组比较亦具统计学意义 ( P<0 .0 5 )。结论 :肝硬化合并消化性溃疡难以治愈 ,且易合并出血 ,门静脉高压因素可能从中发挥了作用 ,小剂量普萘洛尔有助于肝硬化合并消化性溃疡的愈合。
Objective: To study the clinical characteristics of posthepatitic cirrhosis with peptic ulcer and to explore the effect of small doses of propranolol on the healing of liver cirrhosis with peptic ulcer. Methods: Forty-five patients with posthepatitic cirrhosis and peptic ulcer were randomly divided into treatment group (group A) 23 cases, oral propranolol plus cimetidine; control group 1 (group B) 22 cases, oral vitamin B6 gacitidine. Another menu pure peptic ulcer 2 2 cases as a control group 2 (C group), treatment and B group. Results: The median age of patients with liver cirrhosis complicated with peptic ulcer was 12 years later than that of simple peptic ulcer. The ulcer was mainly gastric ulcer with high bleeding rate, which was significantly different from that of C group (P <0.01) ). Propranolol can significantly improve the healing rate of liver cirrhosis with peptic ulcer, compared with the B group was also statistically significant (P <0.05). CONCLUSIONS: Cirrhosis with peptic ulcer is difficult to cure, and it is easy to combine with hemorrhage. The portal hypertension may play a role in it. A small dose of propranolol can help to heal cirrhosis and peptic ulcer.