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自 Yoshimoto(1910) 最早应用补体结合试验测出日本血吸虫病人血清中的循环抗体以来,近半个世纪国内外学者常沿用已知血吸虫抗原以检测同种循环抗体,这种检测方法已被视作为经典的血清学免疫反应。直到1958年,Okabe 和 Tanaka 首先从日本血吸虫病人尿中检出了抗原,这为寻找血吸虫病免疫诊断方法,指出了新的途径。Okabe 和 Tanaka 的新发现,引起了许多学者的兴趣和重视。予1967年,Berggren 和Weller 也曾报道,在感染鼠血清中检出了循环抗原。二十多年来,国外不少学者一直在研究循环抗原(作者按:我国不少学者也正在进行这方面的探索)。目前检测循环抗原的研究仍限于实验阶段,该法还不能用作新的血吸虫病免疫诊断方法。尽管如此,在循环抗原研究方面,已取得不少可供参考的结果。
Since Yoshimoto (1910) first detected the circulating antibodies in the serum of Schistosoma japonicum by complement fixation test, nearly half a century of domestic and foreign scholars often used the known schistosome antigen to detect the same circulating antibodies. This method of detection has been considered as Classic serological immune response. It was not until 1958 that Okabe and Tanaka first detected antigens in the urine of Japanese schistosomiasis, indicating a new way of finding an immune diagnosis of schistosomiasis. The new discoveries of Okabe and Tanaka have aroused the interest and attention of many scholars. To 1967, Berggren and Weller also reported that circulating antigens were detected in infected rat serum. For more than two decades, many foreign scholars have been studying circulating antigens (Author: Many Chinese scholars are also ongoing exploration in this area). The current research on detection of circulating antigen is still limited to the experimental stage, and the method can not be used as a new immune diagnosis method for schistosomiasis. In spite of this, a great deal of reference has been made for the study of circulating antigens.