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在有机溶剂中合成了超顺磁性的油溶性Fe3O4纳米晶.利用相转移的方法成功地将油溶性Fe3O4纳米晶完全转移至水相中,其中两性齐聚物——聚马来酸脂肪胺酯作为修饰剂包裹在Fe3O4纳米晶的表面.利用透射电子显微镜(TEM)、红外光谱仪、热失重分析和动态光散射仪对水溶性纳米晶的形貌和结构进行了表征.所制备的水溶性磁流体在外加磁场的环境中表现出所预期的超顺磁性行为.两性齐聚物中疏水链的长度能够显著地影响相转移效果,研究发现利用含有十六个碳链的聚马来酸十六胺酯来转移纳米晶时效果最好.生物相容性测试实验表明两性齐聚物修饰的Fe3O4纳米晶在各种生理环境中都能够稳定地存在,并没有发生团聚现象.
The superparamagnetic oil-soluble Fe3O4 nanocrystals were synthesized in organic solvent.The phase transfer method was used to successfully transfer the oil-soluble Fe3O4 nanocrystals into the aqueous phase. The amphoteric oligomers, polymaleic fatty acid ester As a modifier on the surface of Fe3O4 nanocrystals.The morphology and structure of water-soluble nanocrystals were characterized by transmission electron microscopy (TEM), infrared spectroscopy, thermogravimetric analysis and dynamic light scattering (DLS) The fluid exhibited the expected superparamagnetic behavior in the presence of a magnetic field.The length of the hydrophobic chains in the amphiphilic oligomers can have a significant effect on the phase transfer effect and it was found that the use of hexadecylamine maleate Ester to transfer the nanocrystals.The biocompatibility test showed that amphiphilic modified Fe3O4 nanocrystals could stably exist in all kinds of physiological environments and did not agglomerate.