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目的:探索皮肤保持其表面pH稳定状态的动力学。方法:利用丙酮和胶带急性破坏表皮通透屏障功能、中波紫外线(UVB)照射及局部外用碱性物质的方法提高皮肤表面pH值。然后,在不同的时间观察皮肤表面pH的改变,依此判断皮肤表面pH保持稳定状态的动力学。结果:在丙酮模型中,表皮通透屏障功能破坏48 h后,皮肤表面的pH恢复正常;而在胶带模型中,表皮通透屏障功能破坏48 h后,皮肤表面的pH值仍明显地高于基础值(P<0.01);在紫外线模型中,UVB照射6 d后,皮肤表面的pH才恢复正常;局部外用碱性物质6 h后,皮肤表面pH恢复正常。结论:皮肤维持其表面pH稳定状态的动力学因诱导pH紊乱的因素不同而不同。
Aims: To explore the kinetics of the skin’s ability to maintain a steady pH on its surface. Methods: The epidermal barrier function of epidermis, ultraviolet (UVB) radiation and topical alkaline substances were used to improve the surface pH of skin by using acetone and adhesive tape. Then, the change of pH on the skin surface was observed at different times, and the kinetics of steady-state pH on the skin surface was judged accordingly. RESULTS: In the acetone model, the pH of the skin surface returned to normal after 48 h of destruction of the epidermal barrier. In the tape model, after 48 h of destruction of the epidermal barrier, the pH of the skin surface was still significantly higher (P <0.01). After UVB irradiation for 6 d, the pH of the skin surface returned to normal in the UV model. After 6 h of topical alkaline solution, the skin surface pH returned to normal. CONCLUSIONS: The kinetics of the skin’s ability to maintain pH stability on its surface vary with the factors that induce pH disturbances.