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为了探讨应激状态下新生儿应用两种不同剂量脂肪乳剂时的脂肪代谢情况，以指导临床合理应用。将１７例胎龄＞３５周，手术后需ＴＰＮ＞１周的新生儿，随机分成低剂量脂肪乳剂组（１ｇ·ｋｇ~（－１）／ｄ）８例，普通剂量对照组（２ｇ·ｋｇ~（－１）／ｄ）９例。在ＴＰＮ前、ＴＰＮ第３天和第７天分别观察ＴＧ、ＴＣ、ＰＬ、ＦＦＡ、ＨＤＬ－Ｃ、ＬＤＬ－Ｃ、Ａｐｏ－Ａ_１和Ａｐｏ－Ｂ变化，结果低剂量组ＴＰＮ１周期间，ＴＧ、ＴＣ、ＰＬ变化不明显，而对照组ＴＧ、ＴＣ在ＴＰＮ第３天升高（但＜１．５０ｇ／Ｌ），第７天回到基值；ＰＬ持续升高，Ａｐｏ－Ａ_１／Ａｐｏ－Ｂ的比值１周变化为：低剂量组１．４７→１．６０→１．４１，对照组１．２０→０．８５→０．９６，它的变化与ＴＧ、ＴＣ等血脂变化相一致。从研究中得出，足月新生儿ＴＰＮ时选用１ｇ·ｋｇ~（－１）／ｄ对血脂几乎没有影响，用２ｇ·ｋｇ~（－１）／ｄ虽然有一过性升高，但仍＜１．５０ｇ／Ｌ，是安全的。
In order to explore the stress state of neonatal fat emulsion when using two different doses of fat metabolism to guide clinical rational use. Seventeen newborns with gestational age> 35 weeks and TPN> 1 week after surgery were randomly divided into 8 groups (1g · kg -1 / d), 2g · kg -1 ~ (-1) / d) in 9 cases. The levels of TG, TC, PL, FFA, HDL-C, LDL-C, Apo-A 1 and Apo-B in TPN were observed before TPN and on the 3rd and 7th day respectively. (P <0.05) .There was no significant difference in PL between the two groups (P <0.05). The levels of TG and TC in the control group increased on the third day of TPN (but <1.50g / L) The ratio of 1 week changes: low dose group 1.47 → 1.60 → 1.41, the control group 1.20 → 0.85 → 0.96, its change and TG, TC and other blood lipid changes consistent. The study concluded that the use of 1g · kg -1 / d of TPN in term neonates had almost no effect on blood lipids, although 2g · kg -1 / d had a transient increase, 1.50g / L, it is safe.