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目的:观察甲状旁腺激素对去卵巢大鼠骨质疏松牙周炎模型骨代谢的影响。方法:4月龄健康雌性Wistar大鼠68只,随机分成4组,每组17只。即A组(健康对照组)、B组(伪手术组)、C组(去势牙周炎组),D组(去势牙周炎加甲状旁腺激素治疗组)。模型建立成功后,A、B、C组腹腔内注射等量的生理盐水,D组间歇性小剂量腹腔内注射等量甲状旁腺激素,隔日注射一次,用药8周。治疗后处死大鼠并通过CBCT扫描测定上颌骨密度,检测血清中钙(Ca2+)、磷(P3+)、碱性磷酸酶(ALP)水平。结果:治疗8周后,经CBCT图像测量,D组上颌骨密度较C组明显升高,差异有统计学意义(P<0.05),与A、B组上颌骨密度无明显差异,无统计学意义(P>0.05)。D组外周血中ALP水平高于A、B、C组(P<0.05),差异有统计学意义,各组血清钙、磷值没有明显改变(P>0.05)。结论:小剂量注射甲状旁腺激素能够增加骨密度并改善外周血中ALP的水平,促进牙槽骨的形成,对绝经期后牙周炎有明显的治疗作用。
Objective: To observe the effects of parathyroid hormone on bone metabolism in osteoporotic periodontitis model of ovariectomized rats. Methods: Sixty-four healthy female Wistar rats were randomly divided into 4 groups with 17 rats in each group. Group A (control group), Group B (sham operation group), Group C (castration periodontitis group), Group D (castration periodontitis plus parathyroid hormone treatment group). After successful establishment of the model, groups A, B and C were injected intraperitoneally with the same amount of normal saline. Group D was intermittently injected with the same dose of parathyroid hormone by intraperitoneal injection once every other day for 8 weeks. After treatment, the rats were sacrificed and the maxillary density was measured by CBCT scanning. The level of Ca2 +, P + and ALP in serum was detected. Results: After 8 weeks of treatment, the maxillary density in group D was significantly higher than that in group C (P <0.05), but no significant difference with group A and B Significance (P> 0.05). The level of ALP in peripheral blood of group D was higher than that of group A, B and C (P <0.05), and the difference was statistically significant (P> 0.05). Conclusion: Small doses of parathyroid hormone can increase bone mineral density and improve the level of ALP in peripheral blood, promote the formation of alveolar bone and have obvious therapeutic effect on periodontitis after menopause.