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几年前哈夫曼-罗氏制药公司瑞士总部发现了一化合物。可以对抗动物在酒精作用下的行为效应,似乎可在致醉的剂量下作用,而无生命威胁。美国国立精神卫生研究院Paul Steven等报告了对该药的研究,明确该药可使酒醉的动物清醒,并提出了其作用的生化基础。药物命名为Ro15-4513,对其用途尚有争论。虽已明确Ro15-4513能作为一种工具,探测酒精如何产生其行为。考虑到解除酒精的法律性及道德性的问题后,哈夫曼-罗氏药厂决定不生产此药供临床用。另一方面,一些研究者认为可以为临床应用.此种想法是制备具有拮抗酒精的作用但无副作用的Ro15-4513长效衍
A few years ago Huffman-Roche found a compound at Swiss headquarters in Switzerland. It can combat the behavioral effects of animals under the action of alcohol and appears to work at a lethal dose without life-threatening threats. The National Institute of Mental Health Paul Steven and others reported on the study of the drug, clearly the drug can make drunk animals awake, and put forward the biochemical basis of its role. Drug named Ro15-4513, its use is still controversial. Although it is clear Ro15-4513 can be used as a tool to detect how alcohol produces its behavior. Taking into account the lifting of the legal and ethical issues of alcohol, Huffman - Roche Pharmaceuticals decided not to produce the drug for clinical use. On the other hand, some researchers believe that it can be used clinically.This idea is to prepare the role of antagonistic alcohol but no side effects of Ro15-4513 long-acting