目的探讨CF化疗方案在乳腺癌新辅助化疗中近期疗效及毒副反应。方法用CF方案对Ⅱ￣Ⅲ期乳腺癌患者进行新辅助化疗2个周期。结果总有效率为67.9%,其中临床完全缓解(cCR)2例,部分缓解(PR)17例,稳定(SD)6例,进展(PD)3例。主要毒副反应为胃肠道反应、骨髓抑制、腹泻、乏力及脱发,但均可耐受。结论CF方案在乳腺癌新辅助化疗中安全、有效,临床应用毒副反应可耐受。 Objective To investigate the short-term curative effect and toxicity of CF chemotherapy in breast neoadjuvant chemotherapy. Methods CF regimen for patients with stage Ⅱ ~ Ⅲ neoadjuvant chemotherapy for 2 cycles. Results The total effective rate was 67.9%. There were 2 cases of clinical complete response (CR), 17 cases of partial remission (PR), 6 cases of stable (SD) and 3 cases of progression (PD). The main side effects of gastrointestinal reactions, bone marrow suppression, diarrhea, fatigue and hair loss, but can be tolerated. Conclusion The CF regimen is safe and effective in the neoadjuvant chemotherapy of breast cancer and its clinical application is tolerable.