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目的比较单核细胞单层检测方法(MMA)与血型血清学方法在诊断ABO系统新生儿溶血病(HDN)中的作用。方法对74名孕妇在孕22周、32周、36周以及新生儿出生当天的血液分别进行抗体效价检测和MMA实验,并对这两种方法进行评价。结果抗体效价检测的灵敏度为80.9%,特异性为73.9%,阴性预示值为65.4%,阳性预示值为79.2%,准确率为74.3%,而MMA的相应评价指标分别为89.4%,85.2%,82.1%,91.3%,和87.8%。结论在早期诊断ABOHDN时,MMA方法较抗体效价测定更为灵敏和准确。
Objective To compare the role of mononuclear cell monolayer assay (MMA) and blood group serological methods in the diagnosis of neonatal hemolytic disease (HDN) in the ABO system. Methods Totally 74 pregnant women were tested for antibody titer and MMA at 22, 32, and 36 weeks of gestation and on the day of their birth, and the two methods were evaluated. Results The antibody titer was 80.9%, specificity was 73.9%, negative predictive value was 65.4%, positive predictive value was 79.2%, accuracy was 74.3%, while the corresponding evaluation index of MMA were 89.4%, 85.2% , 82.1%, 91.3%, and 87.8%. Conclusion In the early diagnosis of ABOHDN, the MMA method is more sensitive and accurate than the antibody titer.