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近年来认为,炎症和免疫是动脉粥样硬化内在和外在危险因素,是致动脉粥样硬化发病的中介和中心环节。骨保护素系统是在破骨细胞分化过程中的一个重要信号传导通路,在多种免疫细胞相互作用方面起调节作用,与动脉硬化性疾病关系密切,且与粥样斑块破裂有关,正在成为急性冠脉综合征研究的热点之一。现对其生物学特点以及在血管钙化和动脉硬化疾病中的作用做一综述。
In recent years, inflammation and immunity are the intrinsic and extrinsic risk factors of atherosclerosis, which is the intermediate and central part of the pathogenesis of atherosclerosis. Osteoprotegerin is an important signal transduction pathway in the process of osteoclast differentiation and plays a regulatory role in the interaction of various immune cells. It is closely related to arteriosclerotic diseases and is related to atherosclerotic plaque rupture and is becoming One of the hot spots in the study of acute coronary syndrome. Now its biological characteristics and vascular calcification and atherosclerosis in the role of review.