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An antimetastatic tetrasaccharide T_1,β-D-Gal-(1→4)-β-D-GlcpNAc-(1→6)-α-D-Manp-(1→6)-β-D-Manp-OMe,was synthesized with two approaches.The first approach was a conventional method employing thioglycoside and Koenigs-Knorr glycosylation reaction in 24%overall yield.The second one was a novel route through the azidoiodo-glycosylation strategy by using 2-iodo-2-deoxylactosyl azide as the donor in 36%overall yield.
An antimetastatic tetrasaccharide T_1, β-D-Gal- (1 → 4) -β-D-GlcpNAc- (1 → 6) -α-D-Manp- synthesized with two approaches. first approach was a conventional method employing thioglycoside and Koenigs-Knorr glycosylation reaction in 24% overall yield. second one was a novel route through the azidoiodo-glycosylation strategy by using 2-iodo-2-deoxylactosyl azide as the donor in 36% overall yield.