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目的:探讨非小细胞肺癌(NSCLC)中P53与NM23/NDPK表达的相关性及其临床意义。方法:采用S-P免疫组化染色技术,检测69例NSCLC中P53及NM23/NDPK的表达情况。结果:P53及NM23/NDPK的表达与患者的生存率有关(P<0.05),P53与NM23/NDPK的表达和肺癌淋巴结转移密切相关(P<0.01)。结论:P53和NM23/NDPK的表达在NSCLC淋巴结转移中起协同作用。联合检测NSCL中P53及NM23/NDPK的表达对于判断预后和指导治疗具有一定的临床价值。
Objective: To investigate the correlation between the expression of P53 and NM23 / NDPK in non-small cell lung cancer (NSCLC) and its clinical significance. Methods: The expression of P53 and NM23 / NDPK in 69 cases of NSCLC were detected by S-P immunohistochemical staining. Results: The expression of P53 and NM23 / NDPK correlated with the survival rate of patients (P <0.05). The expression of P53 and NM23 / NDPK was closely related to lymph node metastasis of lung cancer (P <0.01). Conclusion: The expressions of P53 and NM23 / NDPK play synergistic roles in lymph node metastasis of NSCLC. Joint detection of NSCL in the expression of P53 and NM23 / NDPK for the prognosis and guidance of treatment has some clinical value.