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乙型肝炎病毒 (ＨＢＶ)是一种具有独特结构的嗜肝病毒。ＨＢＶ感染发生后 ,病毒被转运到肝细胞核 ,并在核内从松弛环状ＤＮＡ(ＲＣＤＮＡ)转化为共价闭合环状ＤＮＡ(ｃｃｃＤＮＡ) ,并以ｃｃｃＤＮＡ为模板开始一系列的病毒复制过程 ,因此ＨＢＶｃｃｃＤＮＡ的存在是ＨＢＶ复制
Hepatitis B virus (HBV) is a unique structure of hepadnavirus. After the HBV infection occurs, the virus is transported to the nucleus of the hepatocyte and transforms from the relaxing circular DNA (RCDNA) into covalently closed circular DNA (cccDNA) in the nucleus and starts a series of viral replication processes using cccDNA as a template The presence of HBVcccDNA is HBV replication