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钩藤碱 (rhynchophylline ,Rhy)为中药钩藤的主要活性成分 ,除具有降压、抗心律失常等多种药理作用外 ,近年来研究表明 ,钩藤碱具有拮抗Ca2 + 的作用[1 ] 。因传统的钙拮抗剂能够抑制吗啡的戒断症状[2 ] ,钩藤碱是否也有类似的作用尚不清楚。鉴于此 ,我们在吗啡依赖小鼠催促戒?
Rhynchophylline (Rhynchophylline, Rhy) is the main active ingredient of Uncaria rhynchophylla. Apart from having various pharmacological effects such as antihypertensive and antiarrhythmic, studies in recent years have shown that rhynchophylline can antagonize Ca2 + [1]. Because traditional calcium antagonists can inhibit the withdrawal symptoms of morphine [2], it is unclear whether rhynchophylline has a similar effect. In view of this, we urge morphine-dependent mice to quit?