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细胞色素P450(CYP)氧化酶是许多抗癫药物(AEDs)的代谢酶,许多研究证实CYP基因存在遗传多态性并存在种族差异,其多态性可影响抗癫药物的血药浓度。本文综述了相关的研究进展。
Cytochrome P450 (CYP) oxidase is a metabolic enzyme for many anti-epileptic drugs (AEDs). Many studies have confirmed that there are genetic polymorphisms in CYP gene and racial differences. Polymorphism may affect the plasma concentration of antiepileptic drugs . This article summarizes the related research progress.