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目的了解兴化市疑似预防接种异常反应(AEFI)分布特征,评价监测系统运行情况。方法通过中国疑似预防接种异常反应信息管理系统收集AEFI个案资料,采用描述流行病学方法进行分析。结果兴化市2011—2013年共报告AEFI 632例,报告率为55.12/10万剂。报告病例主要集中在<2岁组(占72.78%),主要发生在接种<1 d(占89.08%),5—7月为高峰(占42.56%)。23种疫苗均发生AEFI,报告反应率居前5位的疫苗分别为无细胞百白破(172.29/10万剂)、结合流脑A+C(167.99/10万剂)、23价肺炎(152.02/10万剂)、白破(112.47/10万剂)、7价肺炎(101.83/10万剂);临床症状以一般反应为主,占97.47%,异常反应占2.37%,偶合反应占0.16%。监测系统个案完整率、及时报告率、及时调查率均为100%。结论兴化市AEFI监测系统运行正常,疫苗安全性预防接种服务质量良好。
Objective To understand the distribution of suspected immunization anomalies (AEFI) in Xinghua City and evaluate the operation of monitoring system. Methods The AEFI case data were collected through the information management system of suspected anaphylaxis in China, and the descriptive epidemiological method was used to analyze the data. Results A total of 632 AEFI cases were reported in Xinghua from 2011 to 2013, with a reported rate of 55.12 / 10 000 doses. Reported cases mainly concentrated in <2-year-old group (72.78%), mainly in <1 d (89.08%) and peaked in May-July (42.56%). AEFI occurred in all 23 kinds of vaccines, and the top 5 vaccines reported were acellular dysentery (172.29 / 10 000 doses), combined with meningitis A + C (167.99 / 10 000), pneumococcal 23 (152.02 / 100 000 doses), white broken (112.47 / 10 000 doses) and 7-valent pneumonia (101.83 / 10 000 doses). The clinical symptoms were mainly general reactions, accounting for 97.47%, abnormal reactions accounting for 2.37% and coupling reactions accounting for 0.16% . Surveillance system case complete rate, timely reporting rate, timely investigation rate was 100%. Conclusion The AEFI monitoring system in Xinghua City is in normal operation and the vaccine safety vaccination service is of good quality.