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应用放射配体结合法检测不同病期被动型Ｈｅｙｍａｎｎ肾炎（ＰＨＮ）病鼠肾、肝胞液糖皮质激素受体（ＧＲ），同时测定相应病期血浆皮质酮（Ｂ）浓度。结果：病鼠第２周末肾胞液ＧＲ最大结合容量（Ｒ_０）较正常大鼠减少（Ｐ＜０．０５）；３周末进一步减少（Ｐ＜０．００５）；４周末Ｒ_０已回升，与正常大鼠差异不显著（Ｐ＞０．０５）。这种动态变化与疾病的发生、发展及转归相一致。肾胞液ＧＲ的Ｒ_０与蛋白量呈负相关（Ｐ＜０．００５），与血肌酐值亦呈负相关（Ｐ＜０．０１）。而肝胞液ＧＲ的Ｒ_０及血浆Ｂ的浓度各病期与正常对照组均无显著差异（Ｐ＞０．０５）。结果提示：ＰＨＮ大鼠肾组织局部ＧＲ减少与ＰＨＮ的发病存在密切联系。
Radioligand binding assay was used to detect glucocorticoid receptor (GR) in renal and hepatic cytokines in passive Heymann nephritis (PHN) and plasma corticosterone (B) concentrations in corresponding phase. Results: Compared with normal rats, the maximum binding capacity (R_0) of renal GR in BALF at the second weekend in rats decreased (P <0.05), decreased further at the third week (P <0.005) There was no significant difference in rats (P> 0.05). This dynamic change is consistent with the occurrence, development and outcome of the disease. Renal cytosolic GR R_0 negative correlation with protein levels (P <0.005), and serum creatinine values were also negatively correlated (P <0.01). However, there was no significant difference in the levels of R_0 and plasma B in liver cells between normal control group and control group (P> 0.05). The results suggest that there is a close relationship between the decrease of local GR in PHN rats and the incidence of PHN.