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动脉粥样硬化(As)所致的缺血性心血管病是当前世界上病死率最高的疾病之一,防治AS是医学领域中的重要课题。省中医研究所顾亚夫主任在总结中西医结合治疗AS的基础上,以养阴清热、止血活血、消浊化瘀的法则拟定血脂平中药复方。由我们承担本课题的实验研究,以观察其对高脂血症、AS斑块的影响。实验方法 1. 动物和分组市售体重1.5—2.5公斤青紫兰雄兔,分笼饲养。在检疫二周中,将食料逐步过渡到实验室基础饲料。剔除患病动物后,继续喂基础饲料10天,测定饥饿时血清总胆固醇(TC)、甘油三脂(TG)和商密度脂蛋白—胆固醇(HDL-C)及其亚组分(HDL_2-C和HDL_3-C),并
Ischemic cardiovascular disease caused by atherosclerosis (As) is one of the most deadly diseases in the world. The prevention and treatment of AS is an important issue in the medical field. Gu Yafu, director of the Provincial Institute of Traditional Chinese Medicine, summed up the traditional Chinese medicine and Western medicine combination therapy based on the principle of nourishing yin, clearing away heat, stopping blood, activating blood, and removing turbid phlegm. We undertake the experimental study of this subject to observe its effect on hyperlipidemia and AS plaques. Experimental methods 1. Animals and subgroups Commercially available 1.5-2.5 kilograms of blue-green male rabbits were housed in separate cages. During the second quarantine, foodstuffs were gradually transferred to the laboratory basal feed. After excluding diseased animals, the basal diet was continued for 10 days. Serum total cholesterol (TC), triglyceride (TG) and HDL-C (HDL-C) and its sub-components (HDL-C) were determined during starvation. And HDL_3-C) and