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目的评价氟哌噻吨美利曲辛联合心理疏导辅佐治疗功能性消化不良的疗效。方法将120例确诊为功能性消化不良的病人分为心理治疗组和对照组各60例,2组均给予复方雷尼替丁胶囊1粒,1日2次,多潘立酮片10mg,1日3次,均饭前口服。心理治疗组加用心理疏导和氟哌噻吨美利曲辛片1片,1日2次,早、中饭后口服,疗程4wk。结果心理治疗组与对照组治疗1、2、4wk后总有效率分别为68%、85%、95%和42%、52%、58%,2组疗效差异非常显著(P<0.01)。治疗4wk后心理治疗组上腹胀痛、上腹烧灼和上腹不适、早饱、嗳气等症状改善积分总有效率分别为94%、93%和93%,明显高于对照组(56%、56%和55%),P<0.01。结论心理和精神药物对伴有焦虑和抑郁症状的功能性消化不良病人治疗效果十分显著,值得临床医师重视和临床推广。
Objective To evaluate the efficacy of flupenthixol combined with melitrace and psychological counseling in the treatment of functional dyspepsia. Methods A total of 120 patients with functional dyspepsia were divided into psychotherapy group and control group, 60 cases in each group. One group received ranitidine capsules twice a day, twice a day, domperidone tablets 10 mg, and three times a day , Before oral administration. Mental treatment group with psychological counseling and flupentixol MTV tablets 1, 1 2 times, early, after oral administration, treatment 4wk. Results The total effective rates of the two groups were 68%, 85%, 95% and 42%, 52% and 58% respectively after treatment for 1, 2 and 4 weeks. The difference between the two groups was significant (P <0.01). After 4 weeks of treatment, the total effective rate of improving symptoms such as abdominal pain, upper abdomen cauterization and upper abdominal discomfort, symptoms of early fullness and belching was 94%, 93% and 93% respectively, which was significantly higher than that of the control group (56% 56% and 55%), P <0.01. Conclusion Psychological and psychiatric drugs have significant therapeutic effects on functional dyspepsia patients with symptoms of anxiety and depression, which is worth clinicians’ attention and clinical promotion.