对８周龄雌性ＮＯＤ鼠分别用优降糖、降糖灵和胰岛素处理２０周。结果显示胰岛素处理组平均血糖低于其它两组也低于对照组，糖尿病发病率也低。病理检查胰岛炎严重程度也显著低于其它三组（Ｐ＜０．０５）。优降糖早期可降低ＮＯＤ鼠血糖，但后期平均血糖值高于其它三组。降糖灵可部分地降低血糖，糖尿病的发生也稍晚于对照组。 Eight-week-old female NOD mice were treated with glibenclamide, hypoglycemic and insulin for 20 weeks respectively. The results showed that the average blood glucose in insulin treatment group is lower than the other two groups is also lower than the control group, the incidence of diabetes is also low. Pathological examination of insulitis severity was significantly lower than the other three groups (P <0.05). The blood glucose of NOD mice was reduced in the early stage of hypoglycemic, but the average blood glucose level of the latter period was higher than the other three groups. Hypoglycemic can partially reduce blood glucose, diabetes was also slightly later than the control group.