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本文通过研究黄体功能不足(LPD)不孕患者服氯菧酚后卵巢的反应及LPD纠正程度,探讨氯菧酚治疗LPD的机理。 25例不孕妇女,子宫内膜组织相皆较月经周期日落后≥3天,参加了对照周期研究,其中18例重复出现内膜发育延迟≥3天,确诊为黄体功能不足。在随后周期第5～9天服氯菧酚100mg/日连续5天,作为试验周期。根据既往月经史在估计LH峰出现日前4天起,指导患者用尿LH试剂盒自测量尿LH水平共51周期,确定LH峰日后在当日取血查LH及E_2浓度,并行阴道超声观察卵泡三维直径。平均卵泡直径≥15mm者定为排卵前卵泡。43周期血LH浓度>30IU/L确定尿LH峰日无误后于LH峰日后7～9天取血测孕酮(P)浓变,10～13天后取内膜由专人行单盲病理检查。
In this paper, we investigated the ovarian response and LPD correction after clopidogrel exposure in patients with infertility due to corpus luteum (LPD) to explore the mechanism of clopidol in the treatment of LPD. 25 cases of infertile women, endometrial tissue phase than the menstrual cycle after sunset ≥ 3 days, participated in the control cycle study, of which 18 cases of repeated intima development delay ≥ 3 days, diagnosed with corpus luteum insufficiency. In the subsequent cycle of 5-9 days clopidol 100mg / day for 5 consecutive days, as the test period. According to the previous menstrual history in the estimated LH peak appeared four days before the start of the patient with urine LH kit self-measurement of urinary LH levels for a total of 51 cycles to determine LH peak blood LH and E_2 concentration on the day to determine the parallel vaginal ultrasound follicular three-dimensional diameter. The average follicle diameter of ≥ 15mm as preovulatory follicles. 43 cycles of blood LH concentration> 30IU / L to determine the urine LH peak day after the LH peak 7 to 9 days blood taken progesterone (P) concentration change, 10 to 13 days after taking the endometrium by a single blind pathological examination.