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目的观察高原地区低分子肝素钙联合高压氧治疗糖尿病足的疗效。方法将44例糖尿病足患者随机分为治疗组和对照组各22例。对照组给予常规内科治疗,治疗组在对照组治疗基础上给予低分子肝素钙联合高压氧治疗,2组均给予足部溃疡局部处理。比较2组临床疗效、治疗前后血液流变学变化及不良事件。结果治疗组总有效率为95.4%高于对照组的77.3%,差异有统计学意义(P<0.05);治疗后治疗组血浆黏度、全血黏度、血液屈服应力、RBC聚集指数、纤维蛋白原水平均低于治疗前及对照组,差异有统计学意义(P<0.05)。2组用药后未出现皮肤及周围组织反应,无局部和全身过敏反应,整个治疗期间未出现消化道大出血或腹腔内脏器出血。结论高原地区低分子肝素钙联合高压氧治疗糖尿病足安全、疗效好。
Objective To observe the therapeutic effect of low molecular weight heparin calcium and hyperbaric oxygen on diabetic foot in plateau area. Methods Forty-four patients with diabetic foot were randomly divided into treatment group and control group with 22 cases each. The control group was given routine medical treatment. The treatment group was given low molecular weight heparin combined with hyperbaric oxygen on the basis of the control group. Both groups were given local treatment of foot ulcer. The clinical curative effect of two groups were compared, the hemorheological changes and adverse events before and after treatment were compared. Results The total effective rate of the treatment group was 95.4%, which was significantly higher than that of the control group (77.3%, P <0.05). After treatment, the plasma viscosity, whole blood viscosity, blood yield stress, RBC aggregation index, fibrinogen The average was lower than before treatment and the control group, the difference was statistically significant (P <0.05). No reaction of the skin and surrounding tissues was found in the two groups, and no local or systemic allergic reaction was found. No gastrointestinal hemorrhage or intra-abdominal organ bleeding occurred during the whole treatment. Conclusion Low molecular weight heparin combined with hyperbaric oxygen in the plateau is safe and effective in treating diabetic foot.