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目的探讨腺性膀胱炎的致病因素。方法将60只SD雌性大鼠随机分成A、B、C3组。A组采用(108~109CFU/100μl)DH5α大肠埃希菌溶液,每隔2d灌注雌性SD大鼠膀胱以诱导产生腺性膀胱炎;B组以人泌尿结石粉末生理盐水混悬液每隔2d灌注膀胱;C组行下尿路梗阻术,B组和C组饮水中加入抗生素饲养。45d后收集膀胱标本进行病理学检查。结果A组膀胱标本的腺性膀胱炎发生率显著高于B组及C组(均P<0.01);B组与C组腺性膀胱炎发生率差异无显著性意义(P>0.05)。结论大肠埃希菌的慢性感染是导致腺性膀胱炎的主要病因。
Objective To investigate the causative factors of cystitis glandularis. Methods Sixty SD female rats were randomly divided into A, B and C3 groups. Group A (108 ~ 109CFU / 100μl) DH5α Escherichia coli solution was used to instil female SD rat bladder every 2d to induce glandular cystitis. Group B was perfused with human urinary stone powder physiological saline suspension every 2d Bladder; C group under the line of urinary tract obstruction, B group and C group drinking water antibiotics feeding. Bladder specimens were collected for pathological examination 45 days later. Results The incidence of cystitis glandula in group A was significantly higher than that in group B and C (all P <0.01). There was no significant difference in the incidence of glandular cystitis between group B and group C (P> 0.05). Conclusion Chronic infection with Escherichia coli is the main cause of cystitis glandularis.