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目的 探讨TNT作业工人早期肝损害健康监护指标。方法 对山东某TNT炸药厂进行劳动卫生学调查 ,并分析TNT作业工人与慢性乙型肝炎患者血糖和血清胆酸含量的变化。结果 车间空气TNT平均浓度超过国家最高容许浓度 (MAC =1mg/m3 ) ,TNT作业工人皮肤TNT污染严重。TNT接触组血糖、血清总胆固醇和胆酸含量显著高于对照组(P <0 0 1)。慢性乙型肝炎组血糖和胆酸含量显著高于对照组 (P <0 0 1) ,其血清总胆固醇含量接近对照组水平。结论 建议血糖及血清胆酸含量的变化可作为TNT作业工人早期肝损伤健康监护指标
Objective To investigate the indicators of health care for early liver damage in TNT workers. Methods A survey of labor hygiene in a TNT explosive factory in Shandong Province was conducted and the changes of blood sugar and serum bile acid levels in TNT workers and chronic hepatitis B patients were analyzed. Results The mean concentration of TNT in the workshop air exceeded the national maximum allowable concentration (MAC = 1 mg / m3). The TNT pollution of TNT workers was serious. The levels of blood glucose, serum total cholesterol and bile acids in TNT exposure group were significantly higher than those in control group (P <0.01). The levels of blood sugar and bile acids in chronic hepatitis B group were significantly higher than those in control group (P <0.01), and the serum total cholesterol levels were close to the control group. Conclusions It is suggested that the changes of blood sugar and serum cholic acid level may be used as indicators of health monitoring of early liver injury in TNT workers