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目的研究脂肪乳剂在治疗慢重肝炎对肝功能和疾病预后的影响。方法同期收治的４４例慢性重症肝炎患者随机分成两组，在均实行综合治疗的基础上，其中一组（治疗组）使用 ２０％脂肪乳剂，对照组则不使用之。观察治疗前后其血清甘油三脂（ＴＧ）、胆红素（ＳＢ）、谷丙转氨酶（ＡＬＴ）、凝血酶原活动度（ＰＴＡ）和治疗后病死率，两组进行比较。结果治疗前两组间ＴＧ、ＳＢ、ＡＬＴ及 ＰＴＡ均无明显差异（ Ｐ＞０． ０５）。治疗结束后，治疗组 ＴＧ平均升高 １． １０ｍｍｏｌ／Ｌ，对照组平均升高 ０． ４４ｍｍｏｌ／Ｌ；有显著差异（Ｐ＜０．０１）；治疗组ＳＢ及ＡＬＴ分别平均降低１２６ｕｍｏｌ／Ｌ和５４９ｕ／Ｌ，对照组则分别平均降低６６ｕｍｏｌ／ＩＬ和４９８ｕｍｏｌ／Ｌ两组间有显著差异（Ｐ＜０． ０５）；治疗组 ＰＴＡ平均升高 ２５个百分点，对照组 ＰＴＡ平均升高 ２３个百分点，两组间无显著差异（ Ｐ＞０． ０５）；两组病死率无显著差异（ Ｐ＞０． ０５）。结论作为重肝治疗中辅助措施，虽然脂肪乳剂不能改善患者凝血功能、降低病死率，但可增加血脂水平、促进血清胆红素及谷丙转氨酶下降，在慢性重症肝炎治疗中是有益的。
Objective To study the effect of fat emulsion in the treatment of chronic hepatitis on the prognosis of liver function and disease. Methods Forty-four patients with chronic severe hepatitis admitted in the same period were randomly divided into two groups. One group (treatment group) used 20% fat emulsion on the basis of comprehensive treatment, but the control group did not. The serum triglyceride (TG), bilirubin (SB), alanine aminotransferase (ALT), prothrombin activity (PTA) and post-treatment mortality were observed before and after treatment. Results There was no significant difference in TG, SB, ALT and PTA between the two groups before treatment (P> 0.05). After treatment, the treatment group TG increased by an average of 1. 10mmol / L, the average increase in the control group 0. (P <0.01); SB and ALT decreased by 126umol / L and 549u / L on average in the treatment group, but decreased by 66umol / IL and 498umol / L in the control group (P <0.05). The average PTA in the treatment group increased by 25% and that in the control group increased by 23% on average (P> 0.05). There was no significant difference between the two groups P> 0.05). Conclusion Although fat emulsion can not improve coagulation function and reduce mortality in patients with severe hepatitis, lipid emulsion can increase blood lipid levels and decrease serum bilirubin and alanine aminotransferase, which is beneficial in the treatment of chronic severe hepatitis.