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为了解难治性肾病患儿血浆脂质代谢的特点，采用生化分析法、酶联免疫法和免疫浊度法分别测定血浆脂质、脂蛋白和载脂蛋白浓度。结果显示：⑴和３０ 例健康儿童相比，１８ 例难治性和１２ 单纯性肾病患儿血浆ＴＣ、ＴＧ、ＬＤＬ－ ｃｈ、ＶＬＤＬ－ ｃｈ 、Ｌｐ（α）、ＡｐｏＢ１００ 均显著升高，且难治性肾病ＴＣ，ＬＤＬ－ ｃｈ 增高更明显，而ＡｐｏＡ１ 升高仅见于单纯性肾病；⑵所有患儿２４ｈ 尿蛋白定量与血浆ＴＧ、ＶＬＤＬ－ｃｈ 呈正相关，血浆Ａｌｂ 与ＴＣ、ＬＤＬ－ｃｈ 呈负相关。说明难治性肾病患儿较单纯性者血浆脂质代谢紊乱更趋严重且更持久，其罹患动脉粥样硬化和肾小球硬化的风险可能更大。
To understand the characteristics of plasma lipid metabolism in children with refractory nephropathy, the levels of plasma lipids, lipoproteins and apolipoproteins were determined by biochemical analysis, enzyme-linked immunosorbent assay and immunoturbidimetric assay respectively. The results showed that: (1) The levels of TC, TG, LDL-ch, VLDL-ch, Lp (α) and ApoB100 in 18 refractory and 12 simple nephrotic children were significantly higher than those in 30 healthy children The levels of TC and LDL-ch in patients with nephridial nephropathy were significantly higher than those in patients with nephrotic syndrome, while the increase of ApoA1 was only found in nephrotic nephropathy. (2) The 24-hour urinary protein in all children was positively correlated with plasma TG and VLDL-ch, Related. This shows that children with refractory renal disease than simple blood lipid disorders more serious and more persistent lipidosis, its risk of developing atherosclerosis and glomerulosclerosis may be greater.