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由于治疗的复杂化,使药物之间相互作用的危险性增加。作者观察7例在接受地戈辛维持量治疗的患者,当加用乙胺碘呋酮(Amiodarone)时,突然出现毒性反应。为此作者研究应用乙胺碘呋酮时血清地戈辛浓度的反应。
Due to the complexity of the treatment, the risk of drug interactions increases. The authors observed seven patients who received denosumab in a dose-dependent manner, with a sudden onset of toxicity when Amiodarone was added. To this end the authors studied the effect of serum amoxicillin on the administration of amiodarone.