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目的:观察银翘三黄膏对糖尿病足溃疡的抑菌作用。方法:将符合标准的患者随机分为单纯西药组和中药治疗组各50例,单纯西药组给予抗感染、改善循环等治疗,局部溃疡无菌换药,给予654-2、普通胰岛素、生理盐水浸润纱条外用;中药治疗组在单纯西药组基础上给予银翘三黄膏外用。观察细菌培养,记录术后创面正常肉芽组织开始生长时间、上皮出现时间及创面愈合时间。结果:治疗前中药治疗组培养细菌例数为50例,治疗后为8例。单纯西药组治疗前培养细菌例数为50例,治疗后为20例。中药治疗组抑制细菌有效率为84%,单纯西药组为60%,2组比较,差异有显著性意义(P<0.05),中药治疗组抑菌作用明显优于单纯西药组。2组正常肉芽组织开始生长时间、上皮出现时间、创面愈合时间比较,差异均有显著性意义(P<0.05)。单纯西药组治疗后有3例不良反应,中药治疗组有2例不良反应,2组比较,差异无显著性意义(P>0.05)。结论:银翘三黄膏外治糖尿病足溃疡对细菌抑菌作用明显,能显著缩短愈合时间,不良反应少,值得临床进一步推广应用。
Objective: To observe the inhibitory effect of Yinqiao Sanhuang cream on diabetic foot ulcer. Methods: The eligible patients were randomly divided into two groups: 50 cases in each group and 50 cases in the traditional Chinese medicine group. Anti-infection and circulation therapy were given in the western medicine group. The aseptic dressing was given to the local ulcer. The rats were given 654-2 normal insulin and normal saline Immersed gauze topical; Chinese medicine treatment group on the basis of pure Western medicine to give Alice three yellow ointment topical. Bacterial culture was observed. The normal granulation tissue began to grow, the appearance of epithelium and wound healing time were recorded. Results: Before treatment, the number of bacteria cultured in traditional Chinese medicine treatment group was 50 cases and 8 cases after treatment. The number of bacteria cultured in pure western medicine group was 50 before treatment and 20 after treatment. The effective rate of inhibiting bacteria in traditional Chinese medicine treatment group was 84% and that in western medicine group was 60%. There was significant difference between the two groups (P <0.05). The antibacterial effect of traditional Chinese medicine treatment group was better than western medicine group. There were significant differences between the two groups (P <0.05) in the beginning of growth, the appearance of epithelium and the healing time of wounds. There were 3 adverse reactions in the pure western medicine group and 2 adverse reactions in the traditional Chinese medicine treatment group. There was no significant difference between the two groups (P> 0.05). Conclusion: Yinqiao three yellow ointment outside the treatment of diabetic foot ulcer bacteria obvious bacteriostasis, can significantly shorten the healing time, adverse reactions, it is worth further clinical application.