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我国是非小细胞肺癌高发国,非小细胞肺癌已经逐渐成为严重危害我国居民健康的疾病之一。目前针对非小细胞肺癌的治疗主要以化疗为主,但由于患者易对化疗药物产生耐药性,长期疗效一直不理想。目前国际上对非小细胞肺癌耐药相关生物标志物进行了很多研究,涉及到临床上多种不同类型的化疗药物,用来指导临床上开展的个体化治疗方案。针对目前临床上常见的几类化疗药物的耐药标志物进行综述,便于非小细胞肺癌患者个体化治疗的开展。
China is a country with high incidence of non-small cell lung cancer, and non-small cell lung cancer has gradually become one of the diseases that seriously endanger the health of our residents. At present, the treatment of non-small cell lung cancer is mainly based on chemotherapy, but because of the patient’s resistance to chemotherapeutic drugs, long-term efficacy has been unsatisfactory. At present, there are many studies on drug-resistance-related biomarkers for non-small cell lung cancer (NSCLC) in the world, involving many different types of chemotherapeutic drugs in the clinic to guide clinically individualized treatment protocols. The current review of drug resistance markers for several types of chemotherapeutic drugs commonly used in clinical practice facilitates the development of individualized treatment for patients with non-small cell lung cancer.