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研究转化生长因子 β1(TGFβ1)与病毒性肝炎肝纤维化的关系。对 45例慢性病毒性肝炎病人肝组织进行了TGFβ1免疫组织化学检测 ,同时检测其中 2 1例血清TGFβ1及血清透明质酸 (HA)、层粘蛋白 (LN)、Ⅳ型胶原 (Ⅳ -C)、Ⅲ型前胶原肽 (PⅢP)水平。结果 :随着肝纤维化程度加重 ,TGFβ1血清水平上升 ,肝内表达逐渐明显 ,二者呈正相关 ;TGFβ1的血清水平及肝内表达与HA、LN、Ⅳ -C、PⅢP四项肝纤维化指标均呈正相关关系。TGFβ1通过活化肝脏间质细胞 ,促进肝脏基质合成加速肝纤维化发展。
To investigate the relationship between transforming growth factor β1 (TGFβ1) and hepatic fibrosis in viral hepatitis. Immunohistochemical detection of TGFβ1 was performed in 45 patients with chronic viral hepatitis and 21 of them serum TGFβ1, serum hyaluronic acid (HA), laminin (LN), collagen Ⅳ (Ⅳ -C) Ⅲ procollagen peptide (P Ⅲ P) levels. Results: As the degree of liver fibrosis increased, the level of serum TGFβ1 increased and the expression in the liver gradually became clear. The levels of TGFβ1 in serum and intrahepatic expression were correlated with the levels of HA, LN, Ⅳ-C and PⅢP All showed a positive correlation. TGFβ1 accelerates hepatic fibrosis by activating hepatic stromal cells and promoting liver matrix synthesis.