孤独症谱系障碍患儿父母感知觉特征与孤独症广泛表型核心特征的相关性

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目的:研究孤独症谱系障碍患儿父母的感知觉特征及其与孤独症广泛表型(broad autism phenotype,BAP)核心特征之间的相关性。方法:选取156名育有至少一名孤独症谱系障碍患儿的父母(ASDp组)为研究对象,同时选取98名性别、年龄及受教育水平相匹配的正常儿童的父母为对照组(TDp组)。使用自编一般情况调查表、青少年/成人感觉史量表(adolescent/adult sensory profile,AASP)以及孤独症广泛表型问卷(broad autism phenotype questionnaire,BAPQ)分别评估两组被试的感知觉及BAP核心特征。采用SPSS 24.0统计软件进行数据分析。使用多元方差分析(MANOVA)比较两组被试AASP量表总分及分量表分间的差异,然后对ASDp组的AASP量表总分、分量表分与BAPQ量表分进行Pearson相关分析。结果:ASDp组AASP总分为(133.67±26.10)分,BAPQ总分为(97.26±21.07)分;TDp组AASP总分为(142.09±27.67)分。与TDp组相比,ASDp组的AASP量表总分(n F=6.852,n P=0.009)以及感觉敏感(n F=7.163,n P=0.008)、感觉回避(n F=12.624,n P<0.001)和低陆录量(n F=7.710,n P=0.006)三个分量表的得分较低,差异具有统计学意义。ASDp组中,AASP总分与BAPQ总分、刻板、冷漠以及实用语言缺陷分量表分均呈正相关(n r=0.557、0.531、0.333、0.571,n P<0.05)。n 结论:孤独症谱系障碍患儿父母感知觉特征与正常儿童父母之间存在差异,且其感知觉特征与已知的BAP核心特征之间存在显著相关性。“,”Objective:To study the perceptual characteristics in parents of children with autism spectrum disorder (ASD), and the correlation between sensory characteristics and the core characteristics of broad autism phenotype (BAP).Methods:A total of 156 parents who have at least one child with autism spectrum disorder (ASDp) were selected as study subjects, while 98 parents of normal children matched by sex, age and education level were selected as control group (TDp). The general information questionnaire, adolescent/adult sensory profile (AASP) and broad autistic phenotype questionnaire (BAPQ) were used to evaluate the perception and BAP core characteristics of the two groups.SPSS 24.0 statistical software was used for data analysis.Multivariate analysis of variance (MANOVA) was used to compare the differences of AASP total scores and subscales scores between the two groups.Then Pearson correlation analysis was conducted for the total scores of the AASP, AASP subscales and BAPQ scale of the ASDp.Results:In ASDp, the total score of AASP was(133.67±26.10), the total score of BAPQ was(97.26±21.07) and the total score of AASP in TDp was(142.09±27.67). Compared with those of TDp, the AASP total score (n F=6.852, n P=0.009), sensory sensitivity (n F=7.163, n P=0.008), sensory avoidance (n F=12.624, n P=0.001) and low logins (n F=7.710, n P=0.006) of ASDp were lower, and the differences were significant.In ASDp, there were significant positive correlations between AASP total score and BAPQ total score, aloof, rigid and pragmatic subscales (n r=0.557, 0.531, 0.333, 0.571, n P<0.05).n Conclusion:There are differences in perceptual characteristics between the parents of children with autism spectrum disorder and parents of normal children, and there is a significant correlation between their perceptual characteristics and the known core characteristics of BAP.
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