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[背景]胎儿发育期间持久性有机污染物(POPs)暴露可以增加儿童期不良健康影响的风险。产妇的特征和妊娠期间的生理变化,例如孕期体重增加(GWG),可能对新生儿的POPs总负荷有一定影响。然而,尚无研究充分阐明GWG与POPs浓度之间的关联。[目的]校正孕前母体的体质指数(BMI)和其他影响POPs转移进入新生儿体内的潜在决定因素之后,研究GWG与脐带血清POPs浓度之间的关联。参考美国医学研究所(IOM)的指南对妊娠妇女进行分组,并估算GWG值。[方法]测定一个西班牙出生队列中325份脐带血清样本中14种有机氯杀虫剂、7种多氯联苯(PCBs)和14种多溴联苯醚(PBDEs)的水平。采用多变量模型估算GWG、孕前BMI和其他产妇的决定性因素与脐带血清POPs浓度的关联。[结果]在校正了年龄、孕前BMI、受教育程度以及鱼类消费等因素后,新生儿的POPs浓度与GWG呈负性相关。平均而言,与GWG不足的母亲所生的新生儿相比,符合IOM建议的GWG妇女所生的新生儿具有较低的POPs浓度。[结论]目前的研究结果提示新生儿POPs暴露与怀孕期间GWG不足之间存在关联。鼓励怀孕妇女达到IOM指南推荐的GWG,可能会降低POPs在新生儿中的蓄积。
[Background] Persistent organic pollutants (POPs) exposure during fetal development can increase the risk of adverse health effects in childhood. Maternal characteristics and physiological changes during pregnancy, such as pregnancy weight gain (GWG), may have some impact on the total POPs burden in the newborn. However, no studies have fully elucidated the correlation between GWG and POPs concentrations. [Objective] To study the association between GWG and cord blood serum POPs after correcting the body mass index (BMI) of pregnant women and other potential determinants that affect the transfer of POPs into the newborn. Refer to the IOM guidelines for grouping pregnant women and estimating GWG values. [Method] The levels of 14 organochlorine pesticides, 7 PCBs and 14 PBDEs in 325 samples of cord blood from a Spanish birth cohort were determined. A multivariate model was used to estimate the association of decisive factors in GWG, pre-pregnancy BMI, and other mothers with cord serum POPs concentrations. [Results] The neonatal POPs concentrations were negatively correlated with GWG after adjusting for factors such as age, pre-pregnancy BMI, educational attainment and fish consumption. On average, newborns born to GWG women who meet IOM recommendations have lower POPs concentrations than newborns born to GWG-deficient mothers. [Conclusions] Current findings suggest a link between neonatal exposure to POPs and inadequate GWG during pregnancy. Encouraging pregnant women to achieve GWP recommended by the IOM guidelines may reduce POPs accumulation in newborns.