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目的：探讨血必净对重症急性胰腺炎患者氧自由基的干预作用。方法收集重症急性胰腺炎患者46例（脱落3例），随机分成对照组22例（脱落2例），血必净组24例（脱落1例），观察患者临床症状缓解情况并测量比较治疗前后 MDA及SOD值。结果与对照组相比患者腹痛缓解时间及胃肠道功能恢复时间缩短，差异有统计学意义（P<0.05）；MDA及SOD值两组治疗后均较治疗前有显著差异，血必净组治疗后较对照组差异有统计学意义（P<0.05）。结论血必净可有效改善患者临床症状，降低重症急性胰腺炎氧自由基水平，是重症急性胰腺炎治疗的有效方案之一。“,”Objective: To investigate the ef ect of Xuebijing on oxygen free radicals in patients with severe acute pancreatitis. Methods: 46 cases of patients with severe acute pancreatitis (fal of 3 cases) were randomly divided into control group 22 cases (fal of 2 cases) and Xuebijing group 24 cases (fal of 1 cases).To investigate their symptoms and monitor MDA and SOD. Results: Compared with the control group,the time of abdominal pain and gastrointestinal function recovery was lower.the dif erence was statistical y significant (P< 0.05); MDA and SOD value of the two groups were significantly dif erent after treatment. Compared with the control group , Xuebijing group had significant dif erence (P< 0.05). Conclusion: Xuebijing can improve clinical symptoms ef ectively and reduce the level of oxygen free radicals in patients with severe acute pancreatitis.It is one of the most ef ective methods in the treatment of severe acute pancreatitis.