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目的探讨孤独症患儿听觉P50的特征及其临床意义,为孤独症的早期诊断找到脑电生理的依据。方法应用美国Nicolet Bravo刺激器,由信号发生器触发使其产生80 dB的成对短声S1(刺激1)和S2(刺激2),S1为条件刺激,S2为测试刺激。首先采用病例对照的方法,对入选的30例孤独症患儿及40名健康对照儿童进行听觉P50的检测,经过20周的系统干预治疗,采用自身对照的方法对30例孤独症患儿进行听觉P50的随访。采用SPSS11.0软件进行数据处理。结果1.孤独症患儿听觉P50抑制明显减弱;健康对照组S1-P50波幅为(5.9±3.6)μV,孤独症组为(3.1±2.4)μV(t=3.70,P<0.05);健康对照组S2-P50波幅为(2.6±2.0)μV,孤独症组为(5.0±3.1)μV(t=3.93,P<0.01);健康对照组波幅S1-S2的差值为(3.8±2.6)μV,孤独症组为(1.5±1.1)μV(t=4.54,P<0.01)。2.孤独症患儿组在干预20周后随访的P50主要指标(S1-P50、S2-P50波潜伏期及波幅,S2-P50波幅/S1-P50波幅的比值,波幅S1-S2的差值)与干预前比较差异均无统计学意义(Pa>0.05)。结论听觉P50变化可能是孤独症患儿所具有的特定生物学指标之一。
Objective To investigate the characteristics and clinical significance of auditory P50 in children with autism and find out the basis of EEG for the early diagnosis of autism. Methods The American Nicolet Bravo stimulator was used to generate 80 dB paired short S1 (stimulus 1) and S2 (stimulus 2) triggered by the signal generator. S1 was the conditioned stimulus and S2 was the test stimulus. First of all, 30 cases of autistic children and 40 healthy control children were enrolled in this study. Auditory P50 was detected in 30 selected children with autism. After 20 weeks of systematic intervention, 30 children with autism P50 follow-up. Using SPSS11.0 software for data processing. Results 1. The P50 inhibition in children with autism decreased significantly. The amplitude of S1-P50 in healthy children was (5.9 ± 3.6) μV and that in autism group was (3.1 ± 2.4) μV (t = 3.70, P <0.05) The amplitude of S2-P50 was (2.6 ± 2.0) μV and that of autism group was (5.0 ± 3.1) μV (t = 3.93, P <0.01) (1.5 ± 1.1) μV (t = 4.54, P <0.01) in autism group. The main indicators of P50 (S1-P50, S2-P50 wave latency and amplitude, S2-P50 amplitude / S1-P50 amplitude ratio and the difference of amplitude S1-S2) There was no significant difference between before and after intervention (Pa> 0.05). Conclusion The change of auditory P50 may be one of the specific biological indicators of children with autism.