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目的：研究乙肝Ⅰ号方对实验性急性肝损伤小鼠抗氧自由基损伤的作用及其机制。方法：采用ｄ－氨基半乳糖急性肝损伤模型，观察小鼠肝匀浆丙二醛（ＭＤＡ）含量、超氧化物歧化酶（ＳＯＤ）及血清酶学改变。结果：乙肝Ⅰ号方防治组与对照组相比，小鼠肝损伤明显减轻，肝匀浆ＭＤＡ含量下降，血清ＡＬＴ降低，降低程度与用药量呈明显的量效关系，且抗氧自由基作用优于乙肝灵冲剂。结论：乙肝Ⅰ号方对实验性急性肝损伤小鼠具有抗自由基损伤的作用
Objective: To study the effect and mechanism of hepatitis B Ⅰ on antioxidant free radical injury in experimental acute liver injury mice. Methods: Acute liver injury model with d-galactosamine was used to observe the changes of malondialdehyde (MDA), superoxide dismutase (SOD) and serum enzyme in the liver of mice. Results: Compared with the control group, the liver injury of Hepatitis B Ⅰ group was significantly reduced, the content of MDA in the liver homogenate was decreased and the serum ALT was decreased. The degree of decrease was significantly dose-dependent and dose-dependent. Better than hepatitis B Ling granules. Conclusion: The effect of hepatitis B Ⅰ on anti-free radical injury in experimental acute liver injury mice