didemnin B是从加勒比海被囊类动物分离出的一种环状缩酚肽类物质,是大量天然海洋动物产品中首次被分离出的具有抗病毒和细胞毒活性的化合物,作为抗肿瘤剂进行临床试验。以前的Ⅰ期临床研究用每28天单次输注30min以上,最大耐受量为3.47mg/m~2,限制剂量的毒性反应是恶心呕吐,其它毒性都很轻微。 didemnin B is a cyclic depsipeptide isolated from the tunicates in the Caribbean and is the first antiviral and cytotoxic compound isolated in a large number of natural marine animal products to act as an antineoplastic agent Clinical Trials. Previous Phase I clinical studies were performed with a single infusion of 30 min or more per day for 28 days, with a maximum tolerated dose of 3.47 mg / m 2. The dose-limiting toxic effects were nausea and vomiting. Other toxicities were mild.