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麦迪霉素(Midemycin)是一种大环内酯类抗生素,对固紫染色阳性菌有明显的抗菌作用。据资料报道,对葡萄球菌、链球菌、肺炎球菌及白喉杆菌等有较强的抗菌活性,对部分耐红霉素的金黄色葡萄球菌亦有抑制作用。麦迪霉素与红霉素不同,属于非诱导肠耐药型抗生素。口服后容易吸收,但因其对胃粘膜有刺激性而制成肠溶片。我们认为,溶厂片有一定缺点:一是加工工序烦锁;二是血中麦迪霉素浓度不高。故参考苏州制药二的效报道对麦迪霉素碱原药经二道加工制成普通胶囊,进行临床观察,收到良好的果。
Midemycin is a macrolide antibiotic that has a significant antibacterial effect on solid purple-stained positive bacteria. According to the information reported, Staphylococcus aureus, streptococcus, pneumococcus and diphtheria bacilli have strong antibacterial activity, some erythromycin-resistant Staphylococcus aureus also inhibited. Midecamycin is different from erythromycin and belongs to the non-induced intestinal drug-resistant antibiotics. Easily absorbed after oral administration, but because of its gastric mucosal irritation made of enteric-coated tablets. We believe that there are some shortcomings dissolution plant films: First, the process annoying lock; Second, the blood concentration of midecamycins is not high. Therefore, reference to the effectiveness of Suzhou Pharmaceutical II reported on the original Madison drug base two processed into ordinary capsules, clinical observation, received a good result.