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肝脏是肿瘤转移扩散的常见部位。迄今仍无有效的方法治疗。有关控制肝转移的发生、发展的机理目前所知甚少。早期用同系小鼠结直肠癌肝转移的肿瘤模型研究证实,小鼠枯否氏细胞(KC)对控制肝转移的发生、发展起着重要作用。其一重要机理是依赖于肿瘤坏死因子(TNF)。据此作者推测人KC也具有抗人结直肠肿瘤细胞系的细胞毒活性。通过了解人KC的细胞毒机理,很有希望制定出适当的刺激人KC的方案,预防或根治肝转移。作者用6例结直肠癌病人手术时切取的一小块
The liver is a common site of tumor metastasis. There is still no effective method of treatment. Little is known about the mechanisms controlling the occurrence and development of liver metastases. Early studies using tumor models of liver metastases in colorectal mice confirmed that mouse Kupffer cells (KC) play an important role in controlling the occurrence and development of liver metastases. An important mechanism is the dependence on tumor necrosis factor (TNF). Based on this, the authors speculate that human KC also has cytotoxic activity against human colorectal tumor cell lines. By understanding the cytotoxic mechanism of human KC, it is hopeful to develop appropriate strategies to stimulate human KC to prevent or cure liver metastases. The author used a small slice of 6 patients with colorectal cancer during surgery