直接涉及矽肺病因方面的免疫学机理问题,仍不明了。在矽肺患者和实验动物模型中所见到的免疫功能的改变,关于这些结果的意义,尚有争论。 据某些研究者推测,矽肺结节病理组织学早已涉及免疫系统。Vigliani和Pernis假定,免疫球蛋白是由病灶周围出现的浆细胞所分泌的。他们同时指出,动物研究中,以异种血清 The issue of immunological mechanisms directly involved in the etiology of silicosis remains unclear. The changes in immune function seen in silicosis patients and experimental animal models are still debated as to the significance of these results. Some researchers speculate that histopathology of silicosis has long been involved in the immune system. Vigliani and Pernis assume that immunoglobulins are secreted by plasma cells that appear around the lesion. They also point out that in animal studies, heterologous sera