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【目的】观察和评价酪酸梭菌活菌散辅助治疗手足口病的临床疗效。【方法】将40例手足口病患儿随机分为治疗组和对照组,治疗组20例,对照组20例,两组均给予注射用利巴韦林(冻干)和注射用重组人干扰素α1 b及对症支持治疗。其中治疗组在治疗的同时加用酪酸梭菌活菌散,1周岁以下0.5 g/次,1周岁以上1 g/次,3次/d,温水送服。对两组疱疹、食欲、体温变化情况及腹泻等并发症进行统计分析。【结果】治疗组起效时间、疱疹消失时间、食欲正常时间和体温恢复正常时间显著短于对照组(P<0.05或<0.01),治疗组治疗后无腹泻和呕吐发生,对照组治疗后4例发生腹泻,1例发生呕吐。【结论】酪酸梭菌活菌散辅助治疗手足口病疗效显著。
【Objective】 To observe and evaluate the clinical efficacy of Clostridium butyricum in the treatment of hand-foot-mouth disease. 【Methods】 Forty children with hand-foot-mouth disease were randomly divided into treatment group and control group, with 20 cases in treatment group and 20 cases in control group. Ribavirin for injection (freeze-dried) and recombinant human interferon for injection Alpha α1 b and symptomatic and supportive treatment. Including the treatment group plus Clostridium butyricum live bacteria scattered, less than 1 year of age 0.5 g / time, 1 year old and above 1 g / time, 3 times / d, warm water delivery service. The two groups of herpes, appetite, temperature changes and diarrhea and other complications were statistically analyzed. 【Results】 The onset time, herpes disappearance time, normal appetite time and body temperature returned to normal in the treatment group were significantly shorter than those in the control group (P <0.05 or <0.01). No diarrhea and vomiting occurred in the treatment group. After treatment, 4 Cases of diarrhea, vomiting occurred in 1 case. 【Conclusion】 Clostridium butyricum Clostridium Powder is effective in treating hand-foot-mouth disease.